Search Criteria: Bone and Muscle Studies;
Amniotic Fluid Epidural Injection for People with Low Back and Hip Pain caused by pressure on the Spinal Cord
Lumbosacral radicular pain is in the low back and hip caused by pressure on the spinal cord. The human amniotic fluid epidural injection is a new way to reduce this pain. Corticosteroid dexamethasone is the standard of care to improve symptoms. Research is needed to learn which is more effective at helping people with the condition. The information we learn will aid future patients. (IRB#: IRB_00131761)
Barriers to Low Back Pain Healthcare for People who are Underserved
Low back pain can require imaging (taking a picture) and other medical needs of the lumbar, (lower part of the back). People may have issues attending appointments for their lower back pain. These include language and translation services and lack of health insurance. The study wants to learn how to better help people attend their appointments for low back pain. Being in the study requires completing a survey. The questions may ask about needing an interpreter, health insurance, childcare, or transportation. People who need health insurance or an interpreter will be given help to attend the appointment. The study team will gather data to learn how to better help participants attend doctor appointments. Information collected will not identify the persons name, address, or phone number. (IRB#: IRB_00156672)
Cervical Medial Branch Radiofrequency Ablation (CMBRFA) compared to Trident Multi-tined Cannula for People with Cervical Facet Pain
Cervical facet pain is an arthritis-like joint pain that can be chronic and occur in the back and neck of the spine. Cervical medial branch radiofrequency ablation (CMBRFA) is an effective treatment for this health issue. Trident Multi-tined Cannula is also a way to help people with cervical pain. Research is needed to learn the characteristics and effectiveness of Trident Multi-tined Cannula compared to CMBRFA. The information we gain may aid future patients. (IRB#: IRB_00143800)
Improve Technology to Rehabilitate People with Non-Mobility and Mobility Impairment
Smart Technology may be used to help rehabilitate people from injuries. Technology can measure a persons movements such as how they walk. There is a new technology that might reduce the cost and amount of time required to recover from an injury. Research is needed to see if the new technology improves rehabilitation for adults with non-mobility and mobility. (IRB#: IRB_00160259)
Laser Evoked Potentials (LEP) in Patients with Low Back Pain and Healthy Volunteers
People with low back pain may need testing for diagnoses and treatment evaluations. Research is needed to assess if more quantitative measures such as laser evoked potential (LEP) and quantitative sensory testing can be used to tease out differences in patients with low back pain problems and better determine the treatment outcomes. The information we gain may aid future patients. (IRB#: IRB_00158608)
Low-Cost Platelet-Rich Plasma for Managing Orthopedic Complications of Bleeding Disorders
Orthopedic complications can be injuries or diseases that affect the bones, muscles, and joints. Hemarthropathy is due to bleeding disorders, most commonly hemophilia, and can result in severe issues related to chronic amounts of blood in the bodys joints. This causes swelling, pain, and loss of joint function. A serious barrier to treating many patients with bleeding disorders creates higher health risks and costs. Platelet-rich plasma (PRP) injection is a method that can reduce the cost of care while still offering a similar standard of care for patients. This study intends to show that low-cost PRP can be done safely in patients with bleeding disorders, without the need for expensive equipment, while monitoring patient treatment results. People in the study will receive injections for joint conditions. Being in the study requires attending 1 to 2 in-person visits at the study clinic. People will also complete surveys using email, text messages, in person, and/or on the phone. Participation lasts about 6 months. (IRB#: IRB_00177846)
Metformin and Muscle Health Recovery
Times of physical inactivity such as illness, recovery from surgery, or injury in older adults may harm muscle health. Research is needed to learn of ways to improve the muscle response to physical activity and recovery. We will determine if metformin, a diabetes drug, improves muscle recovery during physical inactivity. The information we gain may allow us to better design ways to help muscle health when older adults or those who are overweight become physically inactive and have rehabilitation. (IRB#: IRB_00175808)
MODEL Study: SB-01, A Study Drug for People with Degenerative Disc Disease in the Lower Back of the Spine
Degenerative disc disease can occur in the lower back of a persons spine. This disease can cause severe back pain and cause disability. SB-01 is a study drug to help people with this disease. Research is needed to study the safety and effectiveness of this drug. The information we gain may aid future patients. (IRB#: IRB_00154298)
Percutaneous Peripheral Nerve Stimulation (PNS): A Therapy for People with Chronic Low Back Pain (LBP)
Chronic low back pain (LBP) is a major health concern for many people. Many current therapies to help LBP do not work well. Percutaneous peripheral nerve stimulation (PNS) has been shown to relieve LBP and improve quality of life. Research is needed to learn the safety and effectiveness of percutaneous PNS. The information we learn may aid future patients. (IRB#: IRB_00132843)
Physical Inactivity and Muscle Health Recovery
Times of physical inactivity such as illness, recovery from surgery, or injury in older adults and those who are overweight may harm muscle health. Research is needed to learn how different markers such as hormones and proteins in the blood and muscle respond to physical activity and recovery. The information we gain may allow us to better design ways to help muscle health when older adults or those who are overweight become physically inactive and have rehabilitation. (IRB#: IRB_00130232)
Platelet-Rich Plasma for Labrum Tears of the Hip
Platelets are small cells found in the blood that help form clots and stop bleeding. Platelet-rich plasma is blood that contains more platelets than normal and can be given to help people with pain. Tears of the Labrum to the hip (the cartilage "suction cup" that holds the ball to the socket of the hip) cause hip pain. The study wants to see if a portion of the patient's blood, the platelets, will help relieve hip pain and function. Participation requires completing surveys by email, text message, in person, and/or by telephone. Medical tests will also be done to track the health of participants. Participants will receive a gift card for the time spent in the study. (IRB#: IRB_00173470)
Radiofrequency Ablation for People with Sacroiliac Joint Pain
Radiofrequency ablation (RFA) is a way to help people with lower back pain. The pain is caused by swelling or arthritis in the sacroiliac joints. This is where the lower spine and pelvis connect in a persons back. Research is needed to compare 2 types of RFA electrodes (an object that allows electricity to enter and leave a persons body safely). We want to learn which electrode works best in reducing joint pain. The information we gain may aid future patients. (IRB#: IRB_00150067)
Shoulder RFA for the Treatment of Non-Surgical Shoulder Pain
Shoulder pain can cause chronic health issues and costs. Currently, there are not many options to help people with this condition. Research is needed to learn the safety and effectiveness of shoulder radiofrequency ablation (SRFA) in patients with specific shoulder pain. The information we gain may aid future patients. (IRB#: IRB_00159158)
Testing Meditation Group Therapy for Chronic Low Back Pain
This study is comparing therapy to treat people with chronic (constant) low back pain. The study is testing usual care for people using opioids (medication to treat people's pain) versus usual care for people using opioids with meditation-based therapy (mental training involving focusing the mind to cope with pain, stress, and emotions). The study wants to better understand how well the usual care with meditation-based therapy works and if it creates changes in brain activity over time. People in the study will be randomly chosen to be treated with or without meditation therapy. Being in the study lasts about 6 months. Medical tests will be done during the study to learn and track the health of participants. People with be paid for participation. (IRB#: IRB_00133405)
The SPRINT® System a Nerve Stimulator for People with Head Pain
The SPRINT® system can block nerves that send pain signals to the brain. Research is needed to learn how safe the SPRINT® system stimulator is and how well it helps people with head pain. The information we gain may aid future patients. (IRB#: IRB_00159617)
Thigh Muscle Changes Following Knee Injury and Surgery
The purpose of this study is to learn more about muscle function after joint injury of the knee. Including the characteristics of muscle changes and whether it is related to how the muscle functions (strength). The information may improve health care and quality of life for people following knee injuries. People will have medical procedures done to see an image of the leg and strength of the leg and have a biopsy (taking a small sample of tissue out of the muscle). Healthy people will attend in person at the study clinic for about 3 hours. People planning to have surgery for the medical condition will attend 3 study visits for a total of about 4-6 hours over 4 months. People will be paid for participation. (IRB#: IRB_00165256)